regbfbp 0.5.1 © 2003-2013 by Turku PET Centre

Estimate the binding potential (BP) from simplified reference tissue model [1]. The model is solved using the basis function approach [2], similar to the RPM program for producing BP images. Parameters: 1) Tissue TAC file (must be corrected for radioactive decay) 2) Name of reference region in tissue file, or name of file containing reference tissue TAC 3) Isotope (C-11, F-18, ...) 4) Result file (existing file is overwritten) Tissue TAC file must contain weights. Options: -min=<value (1/min)> Set minimum value for theta3; it must be >= k2min/(1+BPmax)+lambda. Default is 0.01 min-1. Lambda for F-18 is 0.0063 and for C-11 0.034. -max=<value (1/min)> Set maximum value for theta3; it must be <= k2max+lambda. Default is 0.60 min-1. -nr=<value> Set number of basis functions; default is 5000. -bf=<filename> Basis functions are written in specified DFT file. -E=<Fit end time (min)> Use data from 0 to end time; by default, model is fitted to all frames. -DVR Instead of BP, program saves the DVR (=BP+1) values. -svg=<Filename> Plots of original and fitted TACs are written in specified file in Scalable Vector Graphics (SVG) 1.1 format; specification in http://www.w3.org/TR/SVG/ -fit=<Filename> Fitted regional TACs are written in specified file. -h or --help Print this message and exit. --version or --build Print software build information and exit. --silent Program works silently, printing only error and warning messages. --verbose Program prints more information about what it is doing. References: 1. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. NeuroImage 1996;4:153-158. 2. Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. NeuroImage 1997;6:279-287. See also: dftweigh, dftdecay, logan, lhsrtm, imgbfbp, fitk2 Keywords: DFT, modelling, binding potential This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome to redistribute it under GNU General Public License.