r2t_rtcm 1.1.4 © 2001-2013 by Turku PET Centre
Simulation of PET tissue time-radioactivity concentration curve (TAC) from
reference tissue TAC based on a selected reference tissue input compartment
model.
Available reference tissue input models and model parameters:
FRTM; (Full) reference tissue model; R1, k2, k3, BP [1]
SRTM: Simplified reference tissue model; R1, k2, BP [2]
RRTM: Reduced reference tissue model; R1, k2, k3 (k4=0)
TRTM: Transport-limited reference tissue model; R1, k2, k3 [3]
Parameters:
1) Model (FRTM|SRTM|RRTM|TRTM)
2) Name of file containing (only) the reference tissue TAC
3-5/6) Model parameters
6/7) Filename for the simulated TAC
Simulated TACs are saved in DFT format, where columns are:
1) Total tissue activity (Ct)
2) Activity in 1st tissue compartment (Cf)
3) Activity in 2nd tissue compartment (Cb)
Options:
-nosub
TACs of sub-compartments (Cf and Cb) are not written into output file.
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints more information about what it is doing
References:
1. Cunningham VJ, Hume SP, Price GR, Ahier RG, Cremer JE, Jones AKP.
Compartmental analysis of diprenorphine binding to opiate receptors
in the rat in vivo and its comparison with equilibrium data in vitro.
J Cereb Blood Flow Metab 1991;11:1-9.
2. Lammertsma AA, Hume SP. Simplified reference tissue model for PET
receptor studies. NeuroImage 1996;4:153-158.
3. Herholz K, Lercher M, Wienhard K, Bauer B, Lenz O, Heiss W-D.
PET measurement of cerebral acetylcholine esterase activity without
blood sampling. Eur J Nucl Med 2001;28:472-477.
See also:
fit_frtm,
fit_srtm,
fit_rrtm,
fit_trtm,
dftadd,
fr4sim
Keywords: DFT, modelling, simulation, reference tissue, reference input
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.
