arlkup - tpcclib 0.8.0 © 2023 by Turku PET Centre
Calculation of perfusion look-up table from [O-15]H2O blood curve
for usage with PET in vivo autoradiographic (ARG) method.
Usage: arlkup [options] BTAC p fMax start dur lkupfile
Options:
-static=<y|N>
The look-up table integral can be corrected for physical decay as
single frame when static PET scan was performed (y), or dynamically
(N, the default).
-nr=<value>
Set the size of look-up table; 5000 by default.
-h, --help
Display usage information on standard output and exit.
-v, --version
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
-q, --quiet
Suppress displaying normal results on standard output.
-s, --silent
Suppress displaying anything except errors.
Blood TAC (BTAC) must be calibrated and corrected for decay. Sample times
must be in sec unless correctly specified inside the BTAC file.
Concentrations must be in the same units as the units of PET tissue data.
Partition coefficient of water (p) must be given in units mL/mL,
and maximal perfusion (fMax) in units mL/(min*100mL).
Integration start time and duration is given in sec.
Look-up table will contain 2 columns: TTAC integral [sec*kBq/mL] and
blood flow [mL/(min*100mL)].
Example:
arlkup -nr=2000 s1456_blo.fit 0.8 50 0 120 s1456.lkup
References:
1. Raichle ME. Quantitative in vivo autoradiography with positron emission
tomography. Brain Res Rev. 1979;1:47-68.
2. Herscovitch P, Markham J, Raichle ME. Brain blood flow measured with
intravenous H215O. I. Theory and error analysis.
J Nucl Med. 1983;24:782-789.
3. Raichle ME, Martin WRW, Herscovitch P, Mintun MA, Markham J. Brain blood
flow measured with intravenous H215O. II. Implementation and validation.
J Nucl Med. 1983;24:790-798.
4. Ruotsalainen U, Raitakari M, Nuutila P, Oikonen V, Sipila H, Teras M,
Knuuti J, Bloomfield PM, Iida H. Quantitative blood flow measurement of
skeletal muscle using oxygen-15-water and PET.
J Nucl Med. 1997; 38:314-319.
See also: fitdelay, imginteg, imglkup, taclkup, tacunit, imgbfbp, imgflow
Keywords: perfusion, blood flow, radiowater, autoradiography, ARG, look-up table