simshape 2.0.0 © 2001,2008 by Turku PET Centre

Simulates the time-activity curves (TACs) of authentic, Cs(t), and metabolized, Cm(t), radiotracer using the measured total tissue curve, Ct(t), and rate constant k3, based on the shape analysis method (1,2). Command-line parameters: 1) Tissue TAC file 2) k3 3) Filename for simulated Cm(t) Options: -h or --help Print this message and exit -int=<Filename> Interpolated regional TACs are written in DFT format. --version or --build Print software build information and exit --silent Program works silently, printing only error and warning messages --verbose Program prints lots of information about what it is doing. Format of the TAC data are specified in http://www.turkupetcentre.net/analysis/doc/format_dft.html Example: metabolite TAC in tissue is simulated first, saving also the fitted and interpolated total tissue TAC, then the TAC of authentic tracer is calculated by subtraction, and finally all curves are plotted in SVG format: simshape -int=ua1309ct.dft ua1309.dft 0.070 ua1309cm.dft taccalc ua1309ct.dft - ua1309cm.dft ua1309cs.dft tac2svg ua1309sa.svg -s ua1309.dft -l ua1309ct.dft ua1309cs.dft ua1309cm.dft References: 1. Koeppe RA, Frey KA, Snyder SE, Meyer P, Kilbourn MR, Kuhl DE. Kinetic modeling of N-[11C]methylpiperidin-4-yl propionate: alternatives for analysis of an irreversible positron emission tomography tracer for measurement of acetylcholinesterase activity in human brain. J Cereb Blood Flow Metab. 1999;19:1150-1163. 2. Tanaka N, Fukushi K, Shinotoh H, Nagatsuka S, Namba H, Iyo M, Aotsuka A, Ota T, Tanada S, Irie T. Positron emission tomographic measurement of brain acetylcholinesterase activity using N-[11C]methylpiperidin-4-yl acetate without arterial blood sampling: methodology of shape analysis and its diagnostic power for Alzheimer's disease. J Cereb Blood Flow Metab. 2001;21:295-306. See also: fitshape, fitk3, fit_trtm, dftcalc, tac2svg, dftdel, dftadd Keywords: DFT, simulation, reference input, enzyme activity, shape analysis This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome to redistribute it under GNU General Public License.