Simulation of PET tissue time-radioactivity concentration curves (TACs)
from arterial blood (Ca) TACs, based on compartmental model for radiowater.
Model has two parameters, perfusion (blood flow, f) and partition
coefficient of water (p).
Delay (deltat) and dispersion (tau) of arterial input function (AIF),
perfusable tissue fraction (PTF), and arterial volume fraction (Va) can be
included in the simulation.
dAIF(t)/dt = (1/tau)*Ca(T-deltat) - (1/tau)*AIF(T-deltat)
dCt(t)/dt = f*AIF(T) - (f/p)*Ct(T)
Cpet(T)= PTF*Ct(T) + Va*AIF(T)
Usage: sim_h2o [options] parfile [bloodfile simfile]
Options:
-h, --help
Display usage information on standard output and exit.
-v, --version
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
-q, --quiet
Suppress displaying normal results on standard output.
-s, --silent
Suppress displaying anything except errors.
To create a template parameter file, do not enter names for input and
simulated TACs.
If parameter file does not contain units, then per min and per mL units
are assumed for f, p, PTF and Va, and seconds for deltat and tau.
For accurate results, blood TAC should have very short sampling intervals.
See also: b2t_h2o, sim_3tcm, fit_h2o, fit_wrlv, tacadd, simframe
Keywords: TAC, simulation, compartmental model, perfusion, radiowater