perfrat - tpcclib 0.7.8 © 2022 by Turku PET Centre
Calculates perfusion ratio from regional radiowater PET data.
In animal disease models, such as UUO model, one of kidneys is affected
by the disease model and the other kidney serves as reference organ.
Perfusion ratio can be calculated from AUCs of tissue curves without
input function (1, 2). AUCs are limited to the time of the first peak of
the control tissue curve.
Usage: perfrat [options] tacfile reference [outputfile]
Extend or shorten AUC calculation past the peak by specified time
(sec). Positive time extends, negative time shortens the time range.
Force given single reference region for every other TAC.
Display usage information on standard output and exit.
Display version and compile information on standard output and exit.
-d[n], --debug[=n], --verbose[=n]
Set the level (n) of debugging messages and listings.
Suppress displaying normal results on standard output.
Suppress displaying anything except errors.
As an example, if TAC file rabbit34.tac contains tissue regions with names
UUO cortex, UUO medulla, CTRL cortex, CTRL medulla,
then to calculate AUC ratio between UUO and CTRL cortex, and
between UUO and CTRL medulla, enter command
perfrat rabbit34.tac CTRL rabbit34.par
Program calculates AUCs from 0 to the peak time of the individual
reference TAC, and saves AUC ratios in parameter file.
1. Xia et al. Hypertension 2008;51(2):466-473.
2. Gulaldi et al. Biomed Res Int. 2013;835859.
See also: tacpeak, interpol, taccalc, fit_h2o, dftratio
Keywords: TAC, modelling, perfusion, ratio