p2t_fet 1.1 © 2000,2001 by Turku PET Centre Simulates a tissue curve from plasma time-activity curve using specified parameter values and the model introduced for FMISO in article Casciari JJ, Graham MM, Rasey JS. A modeling approach for quantifying tumor hypoxia with [F-18]fluoromisonidaxole PET time-activity data. Med Phys 1995; 22(7):1127-1139. _____ F _____ a*Ka _____ Tissue FETNIM (FMISO): | Cp | -----> | Cc | ------> | Cbp | dCc=(F/Vt)*(Cp-Cc)-(1-n)Ka*Cc |_____| <----- |_____| |_____| F | Bound product: | (1-a)*Ka dCbp=a*Ka*Cc V _____ Cellular diffusable product: | Cdp | dCdp=(1-a)*Ka*Cc-Kb*Cdp |_____| | Extracellular diffusable product: | Kb dCdpe=((1-n)/n)*Kb*Cdp V -(F/(n*Vt))*Cdpe _____ F | Cdpe| Total tissue activity: <----- |_____| Cpet=b1*Cb+ b2*Vt*(Cc+(1-n)*(Cbp+Cdp)+n*Cdpe) Parameters: 1) Plasma file 2) Blood file 3) Calculation time 4-11) F, b1 (=Va), b2, Vt, n, Ka, a, Kb 12) Filename for simulated curves (*.dft) e.g.: p2t_fet o01234ap.dft o01234ab.dft 120 0.20 0.05 1.00 1.00 0.50 0.020 0.36 0.013 o01234simul.dft For accurate results, plasma data should have been fitted to some function and have very short (e.g. 0.1 min) time 'frames', and result data should be converted to PET frames using program fr4sim. Results are saved in DFT format (*.dft) where "regions" are: 1) Total tissue activity Cpet (sum of 2-6) 2) Tissue FETNIM b2*Vt*Cc 3) Bound product b2*Vt*(1-n)*Cbp 4) Cellular diffusable product b2*Vt*(1-n)*Cdp 5) Extracellular diffusable product b2*Vt*n*Cdpe 6) Blood background in tissue b1*Cb