mpatlak 1.1.2 © 2002-2005 by Turku PET Centre

Calculates the influx (uptake) rate constant Ki, using modified Gjedde- Patlak plot (1, 2, 3). Modification by Vesa Oikonen (unpublished). Parameters: 1) Tissue TAC file 2) Name of plasma file OR reference region name in TAC file 3-4) Start and end times for linear fit 5) Result file (existing file is overwritten) [6) Filename for plot data (optional) ] Options: -N SDs are not saved in the results. -mid[=<y|n>] Mid frame times are used (y) or not used (n, default) even if frame start and end times are available. e.g. mpatlak ut1234.dat ut1234ap.dat 10 60 ut1234.res or mpatlak ut1234.dft cer 10 60 ut1234.res ut1234mplot.htm Least-squares line fit method can be selected with following options: -C Traditional regression model (default) -M Median of two-point slopes and intercepts (Cornish-Bowden) -P Perpendicular regression model (4) -R Iterative method (York 1966, Lybanon 1984, Reed 1992) In current program version, the weights are not used in the fit. References: 1. Gjedde A. Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: a re-examination. Brain Res. 1982; 257:237-274. 2. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 1983;3:1-7. 3. Patlak CS, Blasberg RG. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab 1985;5:584-590. 4. Varga J & Szabo Z. Modified regression model for the Logan plot. J Cereb Blood Flow Metab 2002; 22:240-244. See also: patlak, fitk3, lhsolki, rescoll Keywords: DFT, modelling, irreversible uptake, net influx