lhsoldv 1.4.3 © 2002-2012 by Turku PET Centre
Estimates the distribution volume (DV) from compartmental model:
Cp Ct
______ ___________________
| | K1 | k3 | 1-tissue CM
| | --> | -------> | DV=K1/k2
| A | <-- | A <------- B |
| | k2 | k4 | 2-tissue CM
|______| |___________________| DV=(K1/k2)*(1+k3/k4)
The model is transformed to general linear least squares functions [1],
which are solved using Lawson-Hanson non-negative least squares (NNLS)
algorithm [2]. DV is estimated directly without division [3,4,5].
Parameters:
1) Metabolite corrected plasma file
2) Tissue TAC file (*.dft)
3) Fit end time (duration)
4) Result file (existing file is overwritten)
Options:
-ref=<reference region name>
When reference region is defined, DVR can be calculated as DVroi/DVref
-h or --help
Print this message and exit
--version or --build
Print software build information and exit
--silent
Program works silently, printing only error and warning messages
--verbose
Program prints more information about what it is doing.
Options for selection of model:
-0 Akaike weighted avg of 1- and 2-tissue compartment model results [6,7]
-1 Force one-tissue compartment model for all regions
-2 Force two-tissue compartment model for all regions
-A Automatic selection of model for separate regions (default)
Example:
lhsoldv ua2918ap_pure.kbq ua2918.dft 90 ua2918dv.res
References:
1. Blomqvist G. On the construction of functional maps in positron emission
tomography. J Cereb Blood Flow Metab 1984;4:629-632.
2. Lawson CL & Hanson RJ. Solving least squares problems.
Prentice-Hall, 1974.
3. Zhou Y, Brasic J, Endres CJ, Kuwabara H, Kimes A, Contoreggi C, Maini A,
Ernst M, Wong DF. Binding potential image based statistical mapping for
detection of dopamine release by [11C]raclopride dynamic PET.
NeuroImage 2002;16(3):S91.
4. Zhou Y, Brasic JR, Ye W, Dogan AS, Hilton J, Singer HS, Wong DF.
Quantification of cerebral serotonin binding in normal controls and
subjects with Tourette's syndrome using [11C]MDL 100,907 and
(+)[11C]McN 5652 dynamic PET with parametric imaging approach.
NeuroImage 2004;22(Suppl 2):T98.
5. Hagelberg N, Aalto S, Kajander J, Oikonen V, Hinkka S, Någren K,
Hietala J, Scheinin H. Alfentanil increases cortical dopamine D2/D3
receptor binding in healthy subjects. Pain 2004;109:86-93.
6. Turkheimer FE, Hinz R, Cunningham VJ. On the undecidability among
kinetic models: from model selection to model averaging. J Cereb Blood
Flow Metab 2003; 23: 490-498.
7. Sederholm K. Model averaging with Akaike weights. TPCMOD0016 2003-04-07.
http://www.turkupetcentre.net/reports/tpcmod0016.pdf
See also:
dftcbv,
dftweigh,
tac2svg,
logan,
fitk2,
fitk4,
imglhdv,
rescoll
Keywords: DFT, modelling, distribution volume, Vt, NNLS
This program comes with ABSOLUTELY NO WARRANTY. This is free software, and
you are welcome to redistribute it under GNU General Public License.
