imglk3 0.1.0 © 2006 by Turku PET Centre

Estimation of lambda*k3 (lambda=K1/k2) from dynamic PET images in ECAT 6.3 or 7.x format applying the irreversibe two-tissue compartment model [1, 2]: 1) Ki is calculated using the average of graphical analysis (Gjedde-Patlak) slopes between time range tGA1-tGA2 (see below). 2) K1 is estimated with bilinear regression between time ranges 0-tBR1 and 0-tBR2 [2]. 3) Lambda*k3 is calculated as lambda*k3=K1*Ki/(K1-Ki). Parameters: 1) Input file (Arterial plasma corrected for metabolites and delay time; times in minutes) 2) Dynamic PET image file 3) tGA1 (Gjedde-Patlak linear fit start time; min) 4) Lambda*k3 image file Options: -Thr=<threshold%> Pixels with AUC less than (threshold/100 x max AUC) are set to zero. Default is 10 % -K1=<filename> K1 image is saved. -Ki=<filename> Ki image is saved. -F Remove parametric pixel values that are over 4x higher than their closest neighbours. -tGA2=<time> Gjedde-Patlak linear fit end time (min). By default, all PET data is used. -tBR1=<time (min)> K1 results are calculated starting from range 0-tBR1; by default, 5 min. -tBR2=<time (min)> K1 results are calculated until range 0-tBR2; by default, 18 min. -h or --help Print this message and exit -v, --build or --version Print software build information and exit --silent Program works silently, printing only warnings and error messages. e.g.: imglk3 ua2918ap.parent.kbq ua2918dy1.v 6 ua2918lk3.v References: 1. Fowler JS, Volkow ND, Wang GJ, Logan J, Pappas N, Shea C, MacGregor R. Age-related increases in brain monoamine oxidase B in living healthy human subjects. Neurobiol Aging 1997; 18: 431-435. 2. Logan J, Fowler JS, Volkow ND, Wang G-J, MacGregor RR, Shea C. Reproducibility of repeated measures of deuterium substituted [11C]L-deprenyl ([11C]L-deprenyl-D2) binding in the human brain. Nucl Med Biol 2000; 27:43-49. See also: imgcbv, imglhlk3, imglhk3, ecat2tif Keywords: image, modelling, irreversible uptake This program comes with ABSOLUTELY NO WARRANTY. This is free software, and you are welcome to redistribute it under GNU General Public License.