imglhbdv - tpcclib 0.8.0 © 2023 by Turku PET Centre

Computation of parametric image of blood and distribution volume (Vb and Vt)
from dynamic PET image in ECAT, NIfTI, or Analyze format applying
one-tissue compartmental model with arterial blood input.
The compartmental models are transformed to general linear least squares
functions, which are solved using Lawson-Hanson non-negative least squares
(NNLS) algorithm (1). Vt is estimated directly without division (2, 3, 4).
 
Dynamic PET image and plasma time-activity curve (PTAC) must be corrected
for decay to the tracer injection time.
 
Usage: imglhbdv [Options] btacfile imgfile vbfile vtfile
 
Options:
 -thr=<threshold%>
     Pixels with AUC less than (threshold/100 x BTAC AUC) are set to zero
     default is 0%
 -end=<Fit end time (min)>
     Use data from 0 to end time; by default, model is fitted to all frames.
 -max=<Max value>
     Upper limit for Vt values; by default 1000.
 -withVb
     Vt includes Vb; by default not.
 -irrz
     Set Vt to zero in pixels which seem to have irreversible uptake.
 -bc=<filename>
     Dynamic image with Vb correction is saved.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
The unit of voxel values in the Vt image is (ml blood)/(ml tissue).
 
Example:
  imglhbdv ua3818ab.kbq ua3818dy1.v ua3818vb.v ua3818vt.v
 
References:
1. Lawson CL & Hanson RJ. Solving least squares problems.
   Prentice-Hall, 1974, ISBN 0-89871-356-0.
2. Zhou Y, Brasic J, Endres CJ, Kuwabara H, Kimes A, Contoreggi C, Maini A,
   Ernst M, Wong DF. Binding potential image based statistical mapping for
   detection of dopamine release by [11C]raclopride dynamic PET.
   NeuroImage 2002;16(3):S91.
3. Zhou Y, Brasic JR, Ye W, Dogan AS, Hilton J, Singer HS, Wong DF.
   Quantification of cerebral serotonin binding in normal controls and
   subjects with Tourette's syndrome using [11C]MDL 100,907 and
   (+)[11C]McN 5652 dynamic PET with parametric imaging approach.
   NeuroImage 2004;22(Suppl 2):T98.
4. Hagelberg N, Aalto S, Kajander J, Oikonen V, Hinkka S, Någren K,
   Hietala J, Scheinin H. Alfentanil increases cortical dopamine D2/D3
   receptor binding in healthy subjects. Pain 2004;109:86-93.
 
See also: imglhdv, imglhk3, lhsol, imgdv, imgratio, img2tif
 
Keywords: image, modelling, distribution volume, vascular fraction, NNLS