fitk2di - tpcclib 0.8.0 © 2023 by Turku PET Centre

Non-linear fitting of dual input compartment model, with one tissue
compartment for each input (parent tracer and its labeled metabolite):
 
  _____   K1p   _____   
 | Cap | ----> | Ctp |  
 |_____| <---- |_____|  
          k2p     |     
                km|     
                  v     
  _____   K1m   _____   
 | Cam | ----> | Ctm |  
 |_____| <---- |_____|  
          k2m           
 
Sample times must be in minutes.
 
Usage: fitk2di [Options] ptacfile mtacfile btacfile ttacfile endtime resultfile
 
Options:
 -lim[=<filename>]
     Specify the constraints for model parameters;
     This file with default values can be created by giving this
     option as the only command-line argument to this program.
     Without filename the default values are printed on screen.
 -SD=<y|N>
     Standard deviations are calculated and saved in results (y),
     or not calculated (N, default).
     Program runs a lot faster if SD and CL are not calculated.
 -CL=<y|N>
     95% Confidence limits are calculated and saved in results (y), or
     not calculated (N, default).
 -Vb=<Vb(%)>
     Enter a fixed Vb; fitted by default.
     If Vb (vascular blood volume) is pre-corrected or to be ignored, set
     it to 0; btacfile can be set to 'none'.
 -ref=<Reference region name or filename>
     Specified reference region is fitted using different set of model
     parameter constraints; not necessary if reference region is given
     with one of the following options -BPnd, -BPp, or -DVR.
 -<BPnd|BPp|DVR>=<Reference region name or filename>
     Optional reference region is used to calculate BPnd, BPp, or DVR;
     BPnd=DVroi/DVref-1, BPp=DVroi-DVref, and DVR=DVroi/DVref
 -refVfm=refVfp
     In reference region Vfm is set to equal Vfp=1.
 -mc=<Filename>
     Fit-based metabolite corrected regional TACs are written in the file.
 -fit=<Filename>
     Fitted regional TACs are written in the file.
 -svg=<Filename>
     Fitted and measured TACs are plotted in specified SVG file.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
 
Example 1: fitting with default settings
     fitk2di ia919apc.kbq ia919apm.kbq ia919ab.kbq ia919.dft 60 a919k2di.res
 
Example 2: Vb is constrained to 0%; DVRs are calculated by dividing DVs
by the DV of region 'cer'
     fitk2di -Vb=0 -R=cer p25apc.bld p25apm.bld none p25.tac 60 p25k2di.res
 
See also: fitk2, logan, fitk4, p2t_di, tacweigh, taccbv
 
Keywords: TAC, modelling, distribution volume, reversible uptake, dual-input