bfmh2o - tpcclib 0.8.0 © 2023 by Turku PET Centre

Basis function method (BFM) fitting of one-tissue compartmental water model
to regional PET [O-15]H2O study data (Koeppe et al., 1985; Boellaard et al.,
2005). The model parameters are blood flow (F), partition coefficient
(pWater), and arterial blood volume (Va). Venous radioactivity is assumed to
be the same as the tissue concentration.
Extraction factor of water is assumed to be 1.0.
The blood flow obtained using PET [O-15]H2O techniques reflects tissue
perfusion, since the method is dependent on the tissue exchange of
labelled water. Non-nutritive flow (blood flowing through arteriovenous
shunts) is not measured (Lammertsma & Jones, 1983).
Radioactivity concentration in arterial blood is given in BTAC file, and
data must be corrected for physical decay and time delay.
Radioactivity concentration in tissue region(s) is given in TTAC file, and
data must be corrected for physical decay.
Sample times must be in seconds in all data files, unless specified inside
the files. Fitting time must be given in sec.
Usage: bfmh2o [options] BTAC TTAC fittime results
 -ml or -dl
     In results the units of F and Va will be given per mL or per dL,
     respectively. By default, units are per dL.
     Report blood flow (perfusion) per perfusable tissue volume
     (PET volume minus vascular volume). By default perfusion is reported
     per PET volume.
     Enter a fixed Va; fitted by default.
 -pH2O=<Partition coefficient for water>
     Enter the true partition coefficient for water to report perfusion as
     F=k2*pH2O instead of default F=K1; apparent pH2O is fitted in any case.
     Plots of original and fitted TTACs are written in specified file in
     SVG format.
     Fitted regional TTACs are written in specified file.
 -k2min=<Min k2> and -k2max=<Max k2>
     Enter the minimum and maximum k2 for BFM in units 1/min (for example
     0.01 and 2.5).
 -fmin=<Min K1> and -fmax=<Max K1>
     Enter the minimum and maximum perfusion value for BFM; defaults are
     0.5 and 400 ml/(dl*min), respectively.
 -pmin=<Min p> and -max=<pmax>
     Enter the minimum and maximum value for apparent partition coefficient
     for water; defaults are 0.3 and 1.0 ml/ml, respectively.
     Set number of basis functions; default is 5000.
     Basis function curves are written in specified file.
 -h, --help
     Display usage information on standard output and exit.
 -v, --version
     Display version and compile information on standard output and exit.
 -d[n], --debug[=n], --verbose[=n]
     Set the level (n) of debugging messages and listings.
 -q, --quiet
     Suppress displaying normal results on standard output.
 -s, --silent
     Suppress displaying anything except errors.
     bfmh2o uo1234bl.bld uo1234.tac 999 uo1234f.res
1. Koeppe RA et al. J Cereb Blood Flow metab. 1985;5:224-234.
2. Boellaard R et al. Mol Imaging Biol. 2005;7:273-285.
3. Lammertsma AA, Jones T. J Cereb Blood Flow Metab. 1983;3:416-424.
See also: fitdelay, b2t_h2o, fit_h2o, imgbfh2o, arlkup, fitk2
Keywords: TAC, modelling, perfusion, blood flow, radiowater, 1TCM